Dr Christopher Rose's hepato-neuro laboratory

The article, entitled "Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure," by Cristina Bosoi, has just been accepted for publication.

In this article, we demonstrate how systemic oxidative stress, with hyperammonemia, plays a role in the pathogenesis of brain edema in rats with bile-duct ligation (BDL, a model of chronic liver failure). We observed at the onset of the disease the presence of oxidative stress in the plasma of BDL rats, but not in the brain. We were able to treat rats with an antioxidant, Allopurinol, which decreased brain edema. An analysis of ROS and ammonia temporal resolution in the plasma of BDL rats suggests that systemic oxidative stress might be an important “first hit,” which, followed by increases in ammonia, leads to BE in chronic liver failure.

An article about AST-120, carbon microspheres adsorbent, which lowers ammonia and cerebral edema, is accepted for publication in Hepatology.
Congratulations to the team!

Article on editor's website.

Congratulations to our first student from the lab, Xiaoling Yang, obtaining her master degree!

A review article was published in NCI. Dr Rose discussed about about implication of lactate in hepatic encephalopathy.

Article on editor's website

An article is published about neuropathological changes in pigs.

Article on editor's website

Welcome our summer student for 2010 : Helen. Furthermore, Christian is coming back for a third summer.

We wish them a great summer, full of learning and with a lot of results!

An article by Xiaoling Yang about oxidative stress in portocaval shunts rats is published in Metabolic Brain Disease. Congratulations!

 Article on editor's website

Cristina presented on 2009 December 16th at 12e congrès annuel des étudiants, stagiaires et résidents du CRCHUM the abstract AST-120 (adsorbant sphérique de charbon) atténue l'œdème cérébral et diminue le niveau artériel d'ammoniaque chez les rats avec ligature de voie biliaire.

Furthermore, Cristina received an prize of excellence from département de sciences biomédicales de l'Université de Montréal.

Abstract AST-120 (spherical carbon adsorbent) treatment prevents hyperammonemia and brain edema in cirrhotic rats. by Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay and Christopher F. Rose was accepted to the Canadian Association for the Study of Liver, held on February 27th - march 2nd, at Toronto, Canada.

Cristina will presented our abstract as an oral presentation.

• AST-120 (spherical carbon adsorbent) attenuates brain edema and lowers arterial ammonia in bile-duct ligated rats de Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose
• Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation de Xiaoling Yang, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose

will be presented at AASLD (American Association for the Study of Liver Diseases) on October 30^th to November 3^rd 2009 in Boston.

Furthermore, abstract on AST-120 will be an oral presentation.

• AST-120 (spherical carbon adsorbent) lowers arterial ammonia and attenuates brain edema in bile-duct ligated rats de Cristina R. Bosoi, Christian Parent-Robitaille, Mélanie Tremblay, Christopher F. Rose
• Brain edema is associated with systemic and not central oxidative stress in rats with bile-duct ligation de Xiaoling Yang, Cristina R. Bosoi, Mélanie Tremblay, Christopher F. Rose

Welcome our summer students for 2009 : Jimmy and Patricia. Furthermore, Christian is coming back for a second summer.

We wish them a great summer, full of learning and with a lot of results!

Dr. Rose received a "bourse de carrière" Junior 2 from FRSQ (Fonds de la recherche en santé du Québec).
Congratulations!

Results 2009-2010 (FRSQ)

A paper was accepted for publication in Hepatology.
Article on web site editor

*edit : Also, read an editorial in same issue.

Abstract Synergistic effect of systemic oxidative stress and hyperammonemia are associated with brain edema in rats with chronic liver failure by C.R. Bosoi, X. Yang, W. Jiang, C. Parent-Robitaille, M. Tremblay, C.F. Rose was accepted by European Association for the Study of the Liver (EASL).

Cristina Bosoi will do a presentation of our work at meeting held in Copenhagen, Denmark from April 22-26^th 2009. She will receive a travel grant to cover her expenses, congratulations!

Last paper was published online December 23^rd.

 Article on publisher's website

Congratulations!

Abstract Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure. Cristina R. Bosoi, Xiaoling Yang, Christian Parent-Robitaille, Wenlei Jiang, Mélanie Tremblay, Christopher F. Rose. was accepted by Canadian Association for the Study of the Liver (CASL). It will be presented on March 2009, at Banff (Alberta, Canada).

Cristina was choosen for an oral presentation. Furthermore, she won a travel award to cover her expenses. Congratulations!

Abstract Hyperammonemia does not induce oxidative/nitrosative stress in rats with portacaval anastomosis (CR Bosoi; M Tremblay; CF Rose) will be presented by Cristina Bosoi to l'AASLD (American Association for the Study of Liver Diseases) on October 31^th to November 4^th 2008 in San Francisco.

A second poster Synergistic effect of systemic oxidative stress and hyperammonemia leads to brain edema in rats with chronic liver failure (CR Bosoi, C Parent-Robitaille, M Tremblay, CF Rose) will be presented at SFRBM (Society for Free Radical Biology and Medicine), held in Indianapolis from November 19^th to 23^rd 2008.

Special congratulations for Cristina for her first participations to meetings.

Our new web site will be lauch as soon as possible. English translation will be completed gradually. The adress of web site will be http://www.hepato-neuro.ca

Come back to see us!