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Article in FRBM
The article, entitled "Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure," by Cristina Bosoi, has just been accepted for publication.
In this article, we demonstrate how systemic oxidative stress, with hyperammonemia, plays a role in the pathogenesis of brain edema in rats with bile-duct ligation (BDL, a model of chronic liver failure). We observed at the onset of the disease the presence of oxidative stress in the plasma of BDL rats, but not in the brain. We were able to treat rats with an antioxidant, Allopurinol, which decreased brain edema. An analysis of ROS and ammonia temporal resolution in the plasma of BDL rats suggests that systemic oxidative stress might be an important “first hit,” which, followed by increases in ammonia, leads to BE in chronic liver failure.
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