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Thanks about 24h de science
On behalf of all the members of Dr. Christopher Rose's hepato-neuro laboratory from CRCHUM, we would like to thank you for your visit on May 11th 2012. It was a pleasure to welcome you at what was our very first participation in the 24 heures de science! The experience was very rewarding, and we all appreciated explaining and showing you some of our techniques, which you were able to try out as well. We would like to thank you for your interest, and for all of your questions. We hope to see you again, perhaps once we've moved into our new facilities!
Christopher, Mélanie, Cristina, Christian, Mireille, Ada and Sarah.
Let's see some photos to give you the desire to come back next year for the 8th edition!
Cristina Bosoi wins a Doctorate's Scholarship
24 heures de science
This year, May 11st, we will participate for the first time to the 24 heures de science. This science vulgarisation event offre more than 250 activities of science and technology all around the province of Quebec.
Venez rencontrer les chercheurs de ce laboratoire de recherche fondamentale en sciences neurologiques, qui vous expliqueront leur sujet d'étude: l'encéphalopathie hépatique, un syndrome complexe caractérisé par des modifications du comportement et des changements de personnalité. Les spécialistes de l'équipe du Dr. Christopher Rose vous montreront comment réaliser plusieurs techniques qu’ils utilisent couramment dans le cadre de leur travail et vous pourrez même les essayer sur place!
Liens:
Registration to our activityWebsite of 24 heures de science
Article in Am J Physiol Gastrointest Liver Physiol (2012)
Article, intitled "Nitric Oxide and L-Arginine Metabolism in a Devascularized Porcine Model of Acute Liver Failure", was initiated in Norway. It's about an acute liver failure model in pig. Mechanisms of the nitric oxide (NO) metabolism was studied.
Article available on editor's website.
Article in FRBM
The article, entitled "Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure," by Cristina Bosoi, has just been accepted for publication.
In this article, we demonstrate how systemic oxidative stress, with hyperammonemia, plays a role in the pathogenesis of brain edema in rats with bile-duct ligation (BDL, a model of chronic liver failure). We observed at the onset of the disease the presence of oxidative stress in the plasma of BDL rats, but not in the brain. We were able to treat rats with an antioxidant, Allopurinol, which decreased brain edema. An analysis of ROS and ammonia temporal resolution in the plasma of BDL rats suggests that systemic oxidative stress might be an important “first hit,” which, followed by increases in ammonia, leads to BE in chronic liver failure.
Mémoire M.Sc
Jimmy Huynh, M.Sc. in Biomedical Science, has handed in his thesis.
His project is entitled: "Le rôle de la barrière hémato-encéphalique dans la pathogénèse de l'oedème chez des rats souffrant d'insuffisance hépatique chronique."
Bourses
Christian Parent-Robitaille wins a Master's Scholarship
Paper alert about Bosoi, et al, 2011
Our most recent paper by Bosoi et al., was choosen by Eur J Gastroen Hepat as a important paper in gastroenterology field.
Our article (Bosoi, C.R. et al. (AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile-duct ligated rats. 2011, Hepatology53(6), pp.1995-2002) was selected as reporting important results for gastroenterology field by editors.
Hayes, P. & Plevris, J., 2011. Paper alert. European Journal of Gastroenterology & Hepatology, 23, pp.743-746. doi: 10.1097/MEG.0b013e328349fa17